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Acute magnesium restoration rapidly corrects the PTH level, suggesting the hypomagnesemia affects the release of PTH, rather than its synthesis.
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We hypothesized that PTH is essential for mineral homeostasis during pregnancy and to stimulate skeletal recovery after lactation, and we used Pth-null mice to test this hypothesis.
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When humans or rodents have adequate dietary calcium intake, PTH is normally suppressed to 20% to 30% of prepregnancy values during pregnancy and lactation, and then it rises to prepregnancy levels or higher during the postweaning period in both humans and rodents.
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