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Several deaths have been reported each in the United States and abroad following theophylline toxicity. But total, the variety of circumstances of theophylline toxicity are subsiding as healthcare suppliers are now theophylline not prescribing this agent for asthma. Contraindications & Blackbox WarningsLearn about our commercial Contraindications & Blackbox Warnings data. Buy cheap theophylline pharmacy otc. Heart Rhythm Drugs Medicine grapefruit high apnea. Theophylline where to money order uk. Learn MorePharmacodynamicsTheophylline, an xanthine by-product chemically similar to caffeine and theobromine, is used to deal with bronchial asthma and bronchospasm. IndicationFor the treatment of the signs and reversible airflow obstruction associated with continual asthma and different continual lung ailments, such as emphysema and persistent bronchitis. NameTheophyllineAccession NumberDB00277DescriptionA methylxanthine derivative from tea with theophylline diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant actions. Only small amounts are excreted by the kidney unchanged, and dosage adjustments in renal failure are pointless.Many drugs may intervene with the theophylline metabolism of theophylline.However, caution must be exercised when utilizing different medication which are additionally metabolised by the cytochrome system when dosage adjustments have to be made at the side of the measurement of plasma levels.These embrace the macrolide (e.g. erythromycin) and quinolone (e.g. ciprofloxacin) households of antibiotics which each reduce theophylline clearance to varying levels. theophylline Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed beneath a number of model names similar to Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD. In an theophylline accompanying editorial, 2 physicians referred to as the outcomes “disappointing,” noting that the drug is inexpensive.2 They wrote that interest in theophylline to stop exacerbations stems from its attainable anti-inflammatory properties. However, those findings depend on greater plasma concentrations than those tolerated by patients.

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