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Although no confirmed cases of tardive dyskinesia have been attributed to clozapine, the dosage of clozapine should be lowered or medication discontinued at earliest signs of tardive dyskinesia to prevent irreversible effects.

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Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of clozapine in children with use in other age groups.

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There are important differences between atypical antipsychotics in the relative risk of adverse effects.

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They are not helpful for tardive dyskinesia, however.

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The reduction in the number of white cells in the patients receiving clozapine, necessitating discontinuation of the drug in one patient, is within the range expected on the basis of much larger samples.

After that, they should be performed regularly no less often than once a month while you are on clozapine and for at least 4 weeks after you stop taking it.

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Lamberti suggests monitoring glucose and blood lipid levels, blood pressure and body weight, for patients taking clozapine.

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