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The agency also cited a 2008 study that found similar femur fracture rates among women taking bisphosphonates compared to women not taking the drugs.

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But many questions remain, including who is most at risk for femur fractures and whether the risks outweigh the important benefits of taking a bisphosphonate for many years.

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Ibandronate is an effective and generally well tolerated bisphosphonate that offers an alternative to other bisphosphonates as a first-line treatment for postmenopausal osteoporosis.

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According to the package insert, most cases of osteonecrosis of the jaw have been in cancer patients undergoing dental procedures who received a bisphosphonate by injection, but some have occurred in patients with postmenopausal osteoporosis or other diagnoses who received the drug orally.

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